Prevalence of Three Common Polymorphisms in the A-subunit Gene of Factor XIII in Patients with Coronary Artery Disease

H.P. Kohler; T.S. Futers; P.J. Grant

doi:10.1055/s-0037-1614515

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 81(04): 511-515
DOI: 10.1055/s-0037-1614515

Rapid Communication

Schattauer GmbH

Prevalence of Three Common Polymorphisms in the A-subunit Gene of Factor XIII in Patients with Coronary Artery Disease

Association with FXIII Activity and Antigen Levels

H.P. Kohler

¹From the Unit of Molecular Vascular Medicine, Leeds General Infirmary, University of Leeds, Leeds, UK

,

T.S. Futers

¹From the Unit of Molecular Vascular Medicine, Leeds General Infirmary, University of Leeds, Leeds, UK

,

P.J. Grant

¹From the Unit of Molecular Vascular Medicine, Leeds General Infirmary, University of Leeds, Leeds, UK

› Author Affiliations

Abstract

Summary

Activated blood coagulation factor XIII has an important role in the final stage of the clotting cascade by the covalent crosslinking of α- and γ-fibrin chains. We have recently shown that a functional polymorphism in exon 2, codon 34 of the FXIII A-subunit gene is protective against myocardial infarction. To investigate the prevalence of three other common point mutations in the A-subunit gene (codon 564, C to T, 650 G to A and 651 G to C) and their association with FXIII activity and antigen levels, 275 patients with coronary artery disease and 196 controls were studied. There was no difference in the prevalence of the polymorphisms between patients and controls or between patients with or without MI. Only genotype at codon 564 was associated with FXIII activity with lower activities in subjects possessing the T allele. There was evidence of linkage disequilibrium between codon 34 and codon 564. These results suggest that FXIIIVal34Leu is the only common polymorphism in the coding region of the A-subunit gene of FXIII associated with coronary artery disease.

Full Text

References

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